换一批Type B monoamine oxidase activity in human brain malignant tumors.
摘要：
An increase of monoamine oxidase (MAO) activity was observed in Central Nervous System (CNS) malignant tumors, but the isoform responsible was not identify (Marcozzi et al., 1985). In the present work we report additional data in order to ascertain whether the type A or B MAO isoform is increased in some malignant human tumors of CNS. In the homogenated tissues the amine oxidase activity was determined by the chemiluminescent method, using different and specific substrates or inhibitors of MAO A and B and copper-dependent enzymes. 19 samples from 4 different types of tumors and relative peritumoral tissues were analysed. The highest activity of was imputable to type B MAO.
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作者：
G,Marcozzi [1]
;
O,Befani [2]
;
B,Mondovì [3]
作者单位：
Dept. of Basic and Applied Biology
[1]
University of L'Aquila
[2]
Italy.
[3]
期刊：
主题词：
动物(Animals);血小板(Blood Platelets);脑肿瘤(Brain Neoplasms);女(雌)性(Female);胍类(Guanidines);人类(Humans);男(雄)性(Male);线粒体(Mitochondria);单胺氧化酶(Monoamine Oxidase);单胺氧化酶抑制剂(Monoamine Oxidase Inhibitors);帕吉林(Pargyline);大鼠(Rats);突触体(Synaptosomes);色胺类(Tryptamines)
PMID：
10072212
发布时间：
2015-11-19
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