Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis.
第一作者:
M,Esteller
第一单位:
Tumor Biology, The Johns Hopkins Oncology Center, Baltimore, Maryland 21231, USA.
作者:
主题词
腺嘌呤(Adenine);腺瘤(Adenoma);癌(Carcinoma);结直肠肿瘤(Colorectal Neoplasms);DNA甲基化(DNA Methylation);基因沉默(Gene Silencing);基因, p53(Genes, p53);基因, ras(Genes, ras);鸟嘌呤(Guanine);人类(Humans);O(6)-甲基鸟嘌呤DNA甲基转移酶(O(6)-Methylguanine-DNA Methyltransferase);点突变(Point Mutation);启动区, 遗传(Promoter Regions, Genetic);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction)
PMID
10811111
发布时间
2022-03-21
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Cancer research
2368-71页
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