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Characterization of substance P-membrane interaction by transferred nuclear Overhauser effect.

摘要:

Substance P, one of the mammalian tachykinins, is known to interact strongly with lipid bilayers and this interaction may play a role in the receptor-peptide recognition process. The conformation of substance P bound to vesicles consisting of perdeuterated phosphatidylcholine has been investigated by means of two-dimensional transferred nuclear Overhauser (trNOE) spectroscopy. Nuclear magnetic resonance data analysis resulted in a unique conformational family characterized by a well-defined conformation of the last seven C-terminal amino acids, which consists of a sequence of nonstandard turns following each other in a helix-like manner. The absence of short- or medium-range trNOE in the N-terminal part indicates its structural flexibility.

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作者: S, Augé [1] ; B, Bersch ; M, Tropis ; A, Milon
作者单位: Institut de Pharmacologie et de Biologie Structurale, CNRS, 205 rte de Narbonne, 31077 Toulouse, France. [1]
期刊:
DOI: 10.1002/1097-0282(20001015)54:5<297::AID-BIP10>3.0.CO;2-9
PMID: 10935970
发布时间: 2018-10-18
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