N-methyl-D-aspartate-induced alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA) receptor down-regulation involves interaction of the carboxyl terminus of GluR2/3 with Pick1. Ligand-binding studies using Sindbis vectors carrying AMPA receptor decoys.
第一作者:
Y,Iwakura
第一单位:
Division of Molecular Neurobiology, Brain Research Institute, Niigata University, Asahimachi-dori 1-757, Niigata 951-8585, Japan.
作者:
主题词
动物(Animals);结合部位(Binding Sites);载体蛋白质类(Carrier Proteins);细胞支架蛋白质类(Cytoskeletal Proteins);减量调节(Down-Regulation);导电性(Electric Conductivity);胞吞作用(Endocytosis);遗传载体(Genetic Vectors);海马(Hippocampus);N-甲基天冬氨酸(N-Methylaspartate);神经元(Neurons);核蛋白质类(Nuclear Proteins);膜片钳术(Patch-Clamp Techniques);蛋白激酶抑制剂(Protein Kinase Inhibitors);蛋白质结构, 三级(Protein Structure, Tertiary);蛋白质亚单位(Protein Subunits);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);受体, AMPA(Receptors, AMPA);Sindbis病毒(Sindbis Virus)
DOI
10.1074/jbc.M103125200
PMID
11498531
发布时间
2021-02-09
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