Abrogation of the radiation-induced G2 checkpoint by the staurosporine derivative UCN-01 is associated with radiosensitisation in a subset of colorectal tumour cell lines.
第一作者:
L C,Playle
第一单位:
Cancer Research UK Colorectal Tumour Biology Research Group, Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK.
作者:
医学主题词
生物碱类(Alkaloids);抗肿瘤药(Antineoplastic Agents);结直肠肿瘤(Colorectal Neoplasms);剂量效应关系, 药物(Dose-Response Relationship, Drug);酶抑制剂(Enzyme Inhibitors);G2期(G2 Phase);人类(Humans);辐射增敏药(Radiation-Sensitizing Agents);星状孢子素(Staurosporine);肿瘤细胞, 培养的(Tumor Cells, Cultured);肿瘤干细胞测定(Tumor Stem Cell Assay)
DOI
10.1038/sj.bjc.6600492
PMID
12177808
发布时间
2024-08-24
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