Complex target-oriented total synthesis in the drug discovery process: the discovery of a highly promising family of second generation epothilones.
第一作者:
Alexey,Rivkin
第一单位:
Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10021, USA.
作者:
主题词
抗肿瘤药(Antineoplastic Agents);细胞分裂(Cell Division);药物设计(Drug Design);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);药物稳定性(Drug Stability);埃博霉素类(Epothilones);HCT116细胞(HCT116 Cells);人类(Humans);构效关系(Structure-Activity Relationship)
DOI
10.1021/ja029695p
PMID
12617656
发布时间
2008-01-17
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