换一批Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice.
第一作者：
Michelle A,Blaskovich
第一单位：
Drug Discovery Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA.
作者：
医学主题词
3T3细胞(3T3 Cells);动物(Animals);抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);细胞分裂(Cell Division);DNA结合蛋白质类(DNA-Binding Proteins);人类(Humans);Janus激酶2(Janus Kinase 2);MAP激酶信号系统(MAP Kinase Signaling System);黑色素瘤, 实验性(Melanoma, Experimental);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 裸(Mice, Nude);磷酰化(Phosphorylation);磷酸酪氨酸(Phosphotyrosine);蛋白酪氨酸激酶类(Protein-Tyrosine Kinases);原癌基因蛋白质类(Proto-Oncogene Proteins);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);STAT3转录因子(STAT3 Transcription Factor);信号传导(Signal Transduction);反式激活因子类(Trans-Activators);三萜类(Triterpenes);肿瘤细胞, 培养的(Tumor Cells, Cultured);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
PMID
12649187
发布时间
2022-03-11
- 浏览137
Cancer research
1270-9页
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