A novel structural class of potent inhibitors of NF-kappa B activation: structure-activity relationships and biological effects of 6-aminoquinazoline derivatives.
第一作者:
Masanori,Tobe
第一单位:
Research Division, Sumitomo Pharmaceuticals Co., Ltd., 1-98 Kasugade Naka 3-Chome, Konohana-ku, Osaka 554-0022, Japan.
作者:
主题词
氨基喹啉类(Aminoquinolines);动物(Animals);消炎药, 非甾类(Anti-Inflammatory Agents, Non-Steroidal);角叉菜胶(Carrageenan);水肿(Edema);炎症(Inflammation);半数抑制浓度(Inhibitory Concentration 50);NF-κB(NF-kappa B);喹唑啉类(Quinazolines);大鼠(Rats);脾(Spleen);构效关系(Structure-Activity Relationship);转录激活(Transcriptional Activation);肿瘤坏死因子α(Tumor Necrosis Factor-alpha)
DOI
10.1016/s0968-0896(03)00438-3
PMID
12927847
发布时间
2023-03-09
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