换一批Regulation of M2-type pyruvate kinase from human meningioma by allosteric effectors fructose 1,6 diphosphate and L-alanine.
摘要：
In the present study the mechanism of action of M2-type pyruvate kinase from human meningioma in the simultaneous presence of fructose 1,6 diphosphate and L-alanine was investigated. Purified pyruvate kinase from human meningioma was allosterically inhibited by L-alanine with respect to substrates phosphoenolpyruvate and ADP. The inhibitory effects of L-alanine was partially removed by fructose 1,6 diphosphate. The purified enzyme was slightly susceptible to ATP inhibition.
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作者：
A A,Mellati [1]
;
M,Yücel [2]
;
N,Altinörs [3]
;
U,Gündüz [4]
作者单位：
Biology Department
[1]
Middle East Technical University
[2]
Ankara
[3]
Turkey.
[4]
期刊：
主题词：
腺苷二磷酸(Adenosine Diphosphate);腺苷三磷酸(Adenosine Triphosphate);丙氨酸(Alanine);别构调节(Allosteric Regulation);果糖二磷酸盐类(Fructosediphosphates);人类(Humans);水解作用(Hydrolysis);动力学(Kinetics);脑膜肿瘤(Meningeal Neoplasms);脑膜瘤(Meningioma);磷酸烯醇丙酮酸(Phosphoenolpyruvate);丙酮酸激酶(Pyruvate Kinase)
PMID：
1343845
发布时间：
2014-11-20
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