换一批Design, synthesis, and characterization of a series of cytochrome P(450) 3A-activated prodrugs (HepDirect prodrugs) useful for targeting phosph(on)ate-based drugs to the liver.
第一作者：
Mark D,Erion
第一单位：
Departments of Medicinal Chemistry and Biochemistry, Metabasis Therapeutics, Inc., San Diego, California 92121 USA.
作者：
医学主题词
腺嘌呤(Adenine);动物(Animals);催化作用(Catalysis);阿糖胞苷(Cytarabine);细胞色素P450酶系统(Cytochrome P-450 Enzyme System);药物释放系统(Drug Delivery Systems);药物设计(Drug Design);肝细胞(Hepatocytes);人类(Humans);肝(Liver);男(雄)性(Male);磷酸盐类(Phosphates);磷酸转移酶类(Phosphotransferases);药物前体(Prodrugs);大鼠(Rats);立体异构现象(Stereoisomerism);时间因素(Time Factors);阿糖腺苷(Vidarabine)
DOI
10.1021/ja031818y
PMID
15099098
发布时间
2013-11-21
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