换一批Chromatin acetylation, memory, and LTP are impaired in CBP+/- mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration.
第一作者：
Juan M,Alarcón
第一单位：
Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA.
作者：
医学主题词
乙酰化作用(Acetylation);方差分析(Analysis of Variance);动物(Animals);印迹法, 蛋白质(Blotting, Western);脑源性神经营养因子(Brain-Derived Neurotrophic Factor);CREB结合蛋白质(CREB-Binding Protein);细胞系(Cell Line);染色质(Chromatin);疾病模型, 动物(Disease Models, Animal);强啡肽类(Dynorphins);电生理学(Electrophysiology);胚胎, 哺乳动物(Embryo, Mammalian);兴奋性突触后电位(Excitatory Postsynaptic Potentials);恐惧(Fear);女(雌)性(Female);基因表达(Gene Expression);杂合子(Heterozygote);海马(Hippocampus);人类(Humans);免疫组织化学(Immunohistochemistry);原位杂交(In Situ Hybridization);肾(Kidney);长时程增强(Long-Term Potentiation);男(雄)性(Male);迷宫学习(Maze Learning);记忆(Memory);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 转基因(Mice, Transgenic);运动活动(Motor Activity);神经抑制(Neural Inhibition);神经元(Neurons);核蛋白质类(Nuclear Proteins);磷酸二酯酶抑制剂(Phosphodiesterase Inhibitors);原癌基因蛋白质c-fos(Proto-Oncogene Proteins c-fos);精神运动性行为(Psychomotor Performance);反应时间(Reaction Time);咯利普兰(Rolipram);Rubinstein-Taybi综合征(Rubinstein-Taybi Syndrome);突触囊泡蛋白(Synaptophysin);时间因素(Time Factors);反式激活因子类(Trans-Activators);转染(Transfection)
DOI
10.1016/j.neuron.2004.05.021
PMID
15207239
发布时间
2024-05-30
- 浏览125
Neuron
947-59页
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文
