Patches of mutant p53-immunoreactive epidermal cells induced by chronic UVB Irradiation harbor the same p53 mutations as squamous cell carcinomas in the skin of hairless SKH-1 mice.
第一作者:
Pavel,Kramata
第一单位:
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854-8020, USA. kramata@rci.rutgers.edu
作者:
医学主题词
等位基因(Alleles);动物(Animals);碱基序列(Base Sequence);癌, 鳞状细胞(Carcinoma, Squamous Cell);细胞转化, 肿瘤(Cell Transformation, Neoplastic);密码子(Codon);女(雌)性(Female);基因, p53(Genes, p53);角蛋白细胞(Keratinocytes);小鼠(Mice);小鼠, 无毛(Mice, Hairless);分子序列数据(Molecular Sequence Data);突变, 误义(Mutation, Missense);肿瘤, 辐射性(Neoplasms, Radiation-Induced);皮肤(Skin);皮肤肿瘤(Skin Neoplasms);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53);紫外线(Ultraviolet Rays)
DOI
10.1158/0008-5472.CAN-04-4537
PMID
15867351
发布时间
2008-11-21
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Cancer research
3577-85页
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