换一批Stereolabile chiral compounds: analysis by dynamic chromatography and stopped-flow methods.
摘要：
Enantiomerization and diastereomerization reactions of chiral compounds play a major role in all aspects of chemistry spanning a wide bridge from drug development to supramolecular chemistry. Traditionally, these reactions are studied by variable-temperature NMR spectroscopy and chiroptical methods such as polarimetry. However, powerful complimentary methods based on chromatography and electrophoresis have been developed and applied to a variety of stereolabile chiral compounds. This tutorial review explains the principles, applications, and limitations of dynamic chromatography and chromatographic and electrophoretic stopped-flow analysis for the investigation of isomerization reactions of chiral compounds.
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作者：
Christian,Wolf [1]
作者单位：
Department of Chemistry
[1]
Georgetown University
[2]
Washington DC 20057
[3]
USA. cw27@georgetown.edu
[4]
期刊：
《Chemical Society reviews》
2005年34卷7期595-608页
主题词：
螯合剂(Chelating Agents);色谱法(Chromatography);计算机模拟(Computer Simulation);分子构象(Molecular Conformation);多环化合物(Polycyclic Compounds);立体异构现象(Stereoisomerism);温度(Temperature);热力学(Thermodynamics)
DOI：
10.1039/b502508g
PMID：
15965541
发布时间：
2006-11-15
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