换一批Thiamine models and perspectives on the mechanism of action of thiamine-dependent enzymes.
摘要：
Thiamine dependent enzymes catalyze ligase and lyase reactions near a carbonyl moiety. Chemical models for these reactions serve as useful tools to substantiate a detailed mechanism of action. This tutorial review covers all such studies performed thus far, emphasizing the role of each part around the active site and the conformation of the cofactor during catalysis.
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作者：
Gerasimos,Malandrinos [1]
;
Maria,Louloudi [2]
;
Nick,Hadjiliadis [3]
作者单位：
University of Ioannina
[1]
Department of Chemistry
[2]
Ioannina
[3]
Greece.
[4]
期刊：
主题词：
结合部位(Binding Sites);催化作用(Catalysis);辅酶类(Coenzymes);连接酶类(Ligases);裂合酶类(Lyases);模型, 生物学(Models, Biological);分子结构(Molecular Structure);有机金属化合物(Organometallic Compounds);硫胺素焦磷酸盐(Thiamine Pyrophosphate)
DOI：
10.1039/b514511m
PMID：
16862269
发布时间：
2013-11-21
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