换一批Bleomycin-iron complexes and DNA radiation damage.
摘要：
Radiation in the form of high-energy electrons dose-dependently activates bleomycin-Fe3+ in oxygen-containing DNA solutions. This activation causes a DNA fragmentation and a release of oxidative degradation products from the DNA. During irradiation, bleomycin-chelated Fe3+ is reduced to Fe2+. The kinetics of DNA base propenal-formation (measured by reaction with thiobarbituric acid) and iron-reduction (measured by bathophenanthroline chelation) are similar, with a yield of 1 mol base propenal/6 mol Fe3+ reduced. The activation of bleomycin-Fe3+ by irradiation could be instrumental in the synergistic action of radiotherapy and bleomycin observed on simultaneous administration in vivo.
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作者：
N,Nørskov-Lauritsen [1]
;
P,Ebbesen [2]
;
E J,Demant [3]
;
J M,Christensen
作者单位：
Danish Cancer Society
[1]
Department of Virus and Cancer
[2]
Arhus.
[3]
期刊：
主题词：
博来霉素(Bleomycin);DNA(DNA);DNA损伤(DNA Damage);剂量效应关系, 辐射(Dose-Response Relationship, Radiation);依地酸(Edetic Acid);电泳, 琼脂凝胶(Electrophoresis, Agar Gel);氧化还原(Oxidation-Reduction)
PMID：
1706958
发布时间：
2013-11-21
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