换一批New nitrosoureas and their spin-labeled derivatives influence dopa-oxidase activity of tyrosinase.
摘要：
Tyrosinase is a key enzyme in melanine biosynthesis. The modulating effect of cytostatic agents on DOPA-oxidase activity of tyrosinase could be linked with the drug treatment of melanoma tumors. Two groups of nitrosoureas which influence DOPA-oxidase activity of tyrosinase were studied: new nitrosoureas and their spin-labeled derivatives synthesized in our laboratory. Using Burnett's spectrophotometric method (Burnett et al., 1967) the following effects were established: inhibition by CCNU, inhibition and the activating effects of the other investigated nitrosoureas depend on their physicochemical half-life. The predominant activating effect of the spin-labeled derivatives is due to the nitroxyl radical present in these compounds.
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作者：
M,Rachkova [1]
;
E,Raikova [2]
;
Z,Raikov [3]
作者单位：
Department of Chemistry and Biochemistry
[1]
Medical Institute
[2]
Stara Zagora
[3]
Bulgaria.
[4]
期刊：
主题词：
抗肿瘤药(Antineoplastic Agents);担子菌纲(Basidiomycota);人类(Humans);洛莫司汀(Lomustine);黑色素瘤(Melanoma);一元酚单氧酶(Monophenol Monooxygenase);亚硝基脲化合物(Nitrosourea Compounds);自旋标记物(Spin Labels);构效关系(Structure-Activity Relationship)
PMID：
1769006
发布时间：
2013-11-21
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