换一批Establishment and biochemical properties of cis-diamminedichloroplatinum(II)-resistant A549 lung cancer cells.
摘要：
A 6.2-fold cis-diamminedichloroplatinum(II) (CDDP) resistant human lung cancer cell line (A549/CDDP5), which was capable of proliferating in the presence of 5 microM CDDP, was developed. Compared to the parent cell line, A549/CDDP5 subline had a significantly longer doubling time, increased population of S phase, enhanced sensitivity to 5-FU and elevated activities of dTMP synthase (EC 2.1.1.45) and thymidine kinase (EC 2.7.1.21) by 5.4- and 2.0-fold of the parent cells. These results suggest that the capacity of dTMP synthesis might have an important role in the acquisition of CDDP resistance of A549 cells.
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作者：
N,Yamauchi [1]
;
T,Shiotani [2]
;
Y,Yamaji [3]
;
J,Fujita ;
Y,Hata ;
S,Irino
作者单位：
First Department of Internal Medicine
[1]
Kagawa Medical School
[2]
Japan.
[3]
期刊：
主题词：
细胞分裂(Cell Division);顺铂(Cisplatin);抗药性(Drug Resistance);氟尿嘧啶(Fluorouracil);人类(Humans);动力学(Kinetics);肺肿瘤(Lung Neoplasms);S期(S Phase);胸苷激酶(Thymidine Kinase);胸苷酸合酶(Thymidylate Synthase);时间因素(Time Factors);肿瘤细胞, 培养的(Tumor Cells, Cultured)
PMID：
1844910
发布时间：
2013-11-21
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