Evolution of lipopolysaccharide (LPS) recognition and signaling: fish TLR4 does not recognize LPS and negatively regulates NF-kappaB activation.
第一作者:
María P,Sepulcre
第一单位:
Department of Cell Biology and Histology, Faculty of Biology, University of Murcia, Murcia, Spain.
作者:
医学主题词
氨基酸序列(Amino Acid Sequence);动物(Animals);生物进化(Biological Evolution);印迹法, 蛋白质(Blotting, Western);鱼类(Fishes);基因表达(Gene Expression);人类(Humans);白细胞(Leukocytes);脂多糖类(Lipopolysaccharides);分子序列数据(Molecular Sequence Data);髓样分化因子88(Myeloid Differentiation Factor 88);NF-κB(NF-kappa B);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction);序列同源性, 氨基酸(Sequence Homology, Amino Acid);信号传导(Signal Transduction);Toll样受体4(Toll-Like Receptor 4);转染(Transfection);斑马鱼(Zebrafish)
DOI
10.4049/jimmunol.0801755
PMID
19201835
发布时间
2010-11-18
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