The topical antimicrobial zinc pyrithione is a heat shock response inducer that causes DNA damage and PARP-dependent energy crisis in human skin cells.
第一作者:
Sarah D,Lamore
第一单位:
Department of Pharmacology and Toxicology, College of Pharmacy, Arizona Cancer Center, University of Arizona, Tucson, AZ, USA.
作者:
主题词
腺苷三磷酸(Adenosine Triphosphate);投药, 局部(Administration, Topical);动物(Animals);抗感染药(Anti-Infective Agents);DNA损伤(DNA Damage);成纤维细胞(Fibroblasts);基因表达(Gene Expression);热休克蛋白质类(Heat-Shock Proteins);热休克反应(Heat-Shock Response);人类(Humans);角蛋白细胞(Keratinocytes);角质溶解药(Keratolytic Agents);黑素细胞(Melanocytes);小鼠(Mice);有机金属化合物(Organometallic Compounds);聚ADP核糖聚合酶类(Poly(ADP-ribose) Polymerases);吡啶类(Pyridines);皮肤(Skin)
DOI
10.1007/s12192-009-0145-6
PMID
19809895
发布时间
2024-02-09
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Cell stress & chaperones
309-22页
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