Integral pharmacokinetics of multiple lignan components in normal, CCl4-induced hepatic injury and hepatoprotective agents pretreated rats and correlations with hepatic injury biomarkers.
第一作者:
Yuan,Xie
第一单位:
Key Laboratory of Drug Metabolism and Pharmacokinetics, Key Unit of SATCM for Pharmacokinetic Methodology of TCM Complex Prescription, China Pharmaceutical University, Nanjing, China.
作者:
主题词
丙氨酸转氨酶(Alanine Transaminase);动物(Animals);曲线下面积(Area Under Curve);天冬氨酸氨基转移酶类(Aspartate Aminotransferases);四氯化碳(Carbon Tetrachloride);细胞色素P-450 CYP3A(Cytochrome P-450 CYP3A);二恶茂类(Dioxoles);疾病模型, 动物(Disease Models, Animal);减量调节(Down-Regulation);女(雌)性(Female);水果(Fruit);草药-药物相互作用(Herb-Drug Interactions);木酚素类(Lignans);男(雄)性(Male);植物药疗法(Phytotherapy);植物提取物(Plant Extracts);预防和防护用药(Protective Agents);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);参考值(Reference Values);五味子属(Schisandra)
DOI
10.1016/j.jep.2010.06.038
PMID
20600750
发布时间
2016-11-25
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