换一批
换一批p-Trifluoromethyldiazirinyl-etomidate: a potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels.
第一作者：
S Shaukat,Husain
第一单位：
Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, 32 Fruit Street, Boston, Massachusetts 02114, USA.
作者：
主题词
别构调节(Allosteric Regulation);麻醉药, 全身(Anesthetics, General);动物(Animals);牛(Cattle);大脑皮质(Cerebral Cortex);重氮甲烷(Diazomethane);依托咪酯(Etomidate);女(雌)性(Female);离子通道闸门(Ion Channel Gating);离子通道(Ion Channels);幼虫(Larva);配体(Ligands);光(Light);诱变, 定点(Mutagenesis, Site-Directed);烟碱拮抗剂(Nicotinic Antagonists);卵母细胞(Oocytes);光亲和标记(Photoaffinity Labels);蛋白质亚单位(Protein Subunits);放射配体测定(Radioligand Assay);受体, GABA-A(Receptors, GABA-A);受体, 烟碱(Receptors, Nicotinic);受体, 血清素, 5-HT3(Receptors, Serotonin, 5-HT3);血清素5-HT3受体拮抗剂(Serotonin 5-HT3 Receptor Antagonists);溶解度(Solubility);立体异构现象(Stereoisomerism);构效关系(Structure-Activity Relationship);电鳐(Torpedo);光滑爪蟾(Xenopus laevis);γ氨基丁酸(gamma-Aminobutyric Acid)
DOI
10.1021/jm100498u
PMID
20704351
发布时间
2021-10-20
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