The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice.
第一作者:
Wei,Tang
第一单位:
Department of Orthopaedic Surgery, New York University School of Medicine and NYU Hospital for Joint Diseases, New York, NY 10003, USA.
作者:
主题词
青少年(Adolescent);成年人(Adult);老年人(Aged);动物(Animals);消炎药, 非甾类(Anti-Inflammatory Agents, Non-Steroidal);关节炎, 实验性(Arthritis, Experimental);软骨, 关节(Cartilage, Articular);女(雌)性(Female);人类(Humans);胞间信号肽类和蛋白质类(Intercellular Signaling Peptides and Proteins);配体(Ligands);男(雄)性(Male);小鼠(Mice);小鼠, 近交系(Mice, Inbred Strains);小鼠, 基因敲除(Mice, Knockout);小鼠, 转基因(Mice, Transgenic);中年人(Middle Aged);蛋白质相互作用域和基序(Protein Interaction Domains and Motifs);受体, 肿瘤坏死因子, Ⅰ型(Receptors, Tumor Necrosis Factor, Type I);受体, 肿瘤坏死因子, Ⅱ型(Receptors, Tumor Necrosis Factor, Type II);重组融合蛋白质类(Recombinant Fusion Proteins);重组蛋白质类(Recombinant Proteins);信号传导(Signal Transduction);T淋巴细胞, 调节性(T-Lymphocytes, Regulatory);肿瘤坏死因子α(Tumor Necrosis Factor-alpha);青年人(Young Adult)
DOI
10.1126/science.1199214
PMID
21393509
发布时间
2022-03-30
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