首页> The Journal of clinical investigation> The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors.

The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors.

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第一作者： Lauren L C,Marotta

第一单位： Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

作者： Lauren L C,Marotta ^[1] ; Vanessa,Almendro ; Andriy,Marusyk ; Michail,Shipitsin ; Janina,Schemme ; Sarah R,Walker ; Noga,Bloushtain-Qimron ; Jessica J,Kim ; Sibgat A,Choudhury ; Reo,Maruyama ; Zhenhua,Wu ; Mithat,Gönen ; Laura A,Mulvey ; Marina O,Bessarabova ; Sung Jin,Huh ; Serena J,Silver ; So Young,Kim ; So Yeon,Park ; Hee Eun,Lee ; Karen S,Anderson ; Andrea L,Richardson ; Tatiana,Nikolskaya ; Yuri,Nikolsky ; X Shirley,Liu ; David E,Root ; William C,Hahn ; David A,Frank ; Kornelia,Polyak

作者单位： Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA. ^[1]

医学主题词动物(Animals);乳腺肿瘤(Breast Neoplasms);细胞系, 肿瘤(Cell Line, Tumor);女(雌)性(Female);基因表达谱(Gene Expression Profiling);人类(Humans);白细胞介素6(Interleukin-6);Janus激酶2(Janus Kinase 2);小鼠(Mice);RNA, 小分子干扰(RNA, Small Interfering);STAT3转录因子(STAT3 Transcription Factor);信号传导(Signal Transduction);干细胞(Stem Cells);移植, 异种(Transplantation, Heterologous)

DOI 10.1172/JCI44745

PMID 21633165

发布时间 2022-03-18

基金项目

R03 NS050830/NS/NINDS NIH HHS/United States R33CA12862/CA/NCI NIH HHS/United States P50 CA89383-07/CA/NCI NIH HHS/United States MH079826/MH/NIMH NIH HHS/United States NS50830/NS/NINDS NIH HHS/United States

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