换一批Pharmacokinetic-pharmacodynamic modeling of biomarker response and tumor growth inhibition to an orally available heat shock protein 90 inhibitor in a human tumor xenograft mouse model.
第一作者：
Shinji,Yamazaki
第一单位：
Department of Pharmacokinetics, Pfizer Worldwide Research and Development, San Diego, California 92121, USA. shinji.yamazaki@pfizer.com
作者：
医学主题词
算法(Algorithms);动物(Animals);抗肿瘤药(Antineoplastic Agents);血蛋白质类(Blood Proteins);乳腺肿瘤(Breast Neoplasms);细胞系, 肿瘤(Cell Line, Tumor);色谱法, 高压液相(Chromatography, High Pressure Liquid);女(雌)性(Female);HSP90热休克蛋白质类(HSP90 Heat-Shock Proteins);人类(Humans);小鼠(Mice);小鼠, 裸(Mice, Nude);模型, 统计学(Models, Statistical);癌基因蛋白质v-akt(Oncogene Protein v-akt);蛋白质结合(Protein Binding);吡唑类(Pyrazoles);嘧啶类(Pyrimidines);串联质谱法(Tandem Mass Spectrometry);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1124/jpet.111.181339
PMID
21680888
发布时间
2025-03-06
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