Deletion of CREB-regulated transcription coactivator 1 induces pathological aggression, depression-related behaviors, and neuroplasticity genes dysregulation in mice.
第一作者:
Lionel,Breuillaud
第一单位:
Center for Psychiatric Neuroscience, Prilly-Lausanne, Switzerland.
作者:
主题词
攻击(Aggression);动物(Animals);抗抑郁药, 第二代(Antidepressive Agents, Second-Generation);拟南芥蛋白质类(Arabidopsis Proteins);生物源单胺类(Biogenic Monoamines);脑(Brain);脑源性神经营养因子(Brain-Derived Neurotrophic Factor);色谱法, 高压液相(Chromatography, High Pressure Liquid);皮质酮(Corticosterone);抑郁症(Depressive Disorder);疾病模型, 动物(Disease Models, Animal);电休克(Electroshock);酶联免疫吸附测定(Enzyme-Linked Immunosorbent Assay);探究行为(Exploratory Behavior);恐惧(Fear);女(雌)性(Female);氟西汀(Fluoxetine);偏食(Food Preferences);基因表达调控(Gene Expression Regulation);后肢悬吊(Hindlimb Suspension);分子内转移酶类(Intramolecular Transferases);男(雄)性(Male);母亲行为(Maternal Behavior);迷宫学习(Maze Learning);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);筑巢行为(Nesting Behavior);神经元可塑性(Neuronal Plasticity);孤儿核受体(Orphan Nuclear Receptors);受体, trkB(Receptor, trkB);性行为, 动物(Sexual Behavior, Animal);信号传导(Signal Transduction);社会行为(Social Behavior);游泳(Swimming);转录因子(Transcription Factors)
DOI
10.1016/j.biopsych.2012.04.011
PMID
22592058
发布时间
2022-01-29
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Biological psychiatry
528-36页
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