Berberine attenuates bleomycin induced pulmonary toxicity and fibrosis via suppressing NF-κB dependant TGF-β activation: a biphasic experimental study.
作者:
Palanivel,Chitra [1]
;
Gowrikumar,Saiprasad [2]
;
Ramar,Manikandan [3]
;
Ganapasam,Sudhandiran [4]
作者单位:
Department of Biochemistry
[1]
Cell Biology Laboratory
[2]
University of Madras
[3]
Guindy Campus
[4]
Chennai
[5]
Tamil Nadu
[6]
India.
[7]
期刊:
《Toxicology letters》
2013年219卷2期178-93页
主题词:
动物(Animals);抗代谢药(Antimetabolites);小檗碱(Berberine);博来霉素(Bleomycin);印迹法, 蛋白质(Blotting, Western);支气管肺泡灌洗液(Bronchoalveolar Lavage Fluid);胶原(Collagen);组胺释放(Histamine Release);羟脯氨酸(Hydroxyproline);免疫组织化学(Immunohistochemistry);肺疾病(Lung Diseases);男(雄)性(Male);丙二醛(Malondialdehyde);显微镜检查, 共焦(Microscopy, Confocal);NF-E2相关因子2(NF-E2-Related Factor 2);NF-κB(NF-kappa B);一氧化氮合酶Ⅱ型(Nitric Oxide Synthase Type II);亚硝酸盐类(Nitrites);氧化性应激(Oxidative Stress);过氧化物酶(Peroxidase);肺纤维化(Pulmonary Fibrosis);大鼠(Rats);大鼠, Wistar(Rats, Wistar);转化生长因子β(Transforming Growth Factor beta);肿瘤坏死因子α(Tumor Necrosis Factor-alpha);体重增长(Weight Gain)
DOI:
10.1016/j.toxlet.2013.03.009
PMID:
23523906
发布时间:
2013-11-21
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