The ketamine analogue methoxetamine and 3- and 4-methoxy analogues of phencyclidine are high affinity and selective ligands for the glutamate NMDA receptor.
第一作者:
Bryan L,Roth
第一单位:
NIMH Psychoactive Drug Screening Program, Department of Pharmacology and Division of Chemical Biology and Medicinal Chemistry, University of North Carolina Chapel Hill Medical School, Chapel Hill, North Carolina, United States of America.
作者:
主题词
环己酮类(Cyclohexanones);环己胺类(Cyclohexylamines);药物评价, 临床前(Drug Evaluation, Preclinical);人类(Humans);氯胺酮(Ketamine);分子结构(Molecular Structure);国立精神卫生研究所(美国)(National Institute of Mental Health (U.S.));苯环利定(Phencyclidine);放射配体测定(Radioligand Assay);受体, N-甲基-D-天冬氨酸(Receptors, N-Methyl-D-Aspartate);受体, Σ(Receptors, sigma);血清素质膜转运蛋白质类(Serotonin Plasma Membrane Transport Proteins);美国(United States)
DOI
10.1371/journal.pone.0059334
PMID
23527166
发布时间
2021-10-21
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