换一批Restoration of the activated Rig-I pathway in hepatitis C virus (HCV) replicon cells by HCV protease, polymerase, and NS5A inhibitors in vitro at clinically relevant concentrations.
第一作者：
Gururaj,Kalkeri
第一单位：
Vertex Pharmaceuticals Incorporated, Cambridge, Massachusetts, USA. gururaj_kalkeri@vrtx.com
作者：
医学主题词
衔接蛋白质类, 信号转导(Adaptor Proteins, Signal Transducing);细胞系, 转化(Cell Line, Transformed);DEAD-box RNA解旋酶类(DEAD-box RNA Helicases);指导DNA的DNA聚合酶(DNA-Directed DNA Polymerase);酶抑制剂(Enzyme Inhibitors);基因表达调控(Gene Expression Regulation);肝炎病毒属(Hepacivirus);肝细胞(Hepatocytes);宿主与病原体相互作用(Host-Pathogen Interactions);人类(Humans);干扰素调节因子3(Interferon Regulatory Factor-3);干扰素β(Interferon-beta);线粒体(Mitochondria);核酸合成抑制剂(Nucleic Acid Synthesis Inhibitors);启动区, 遗传(Promoter Regions, Genetic);受体, 免疫(Receptors, Immunologic);复制子(Replicon);仙台病毒(Sendai virus);信号传导(Signal Transduction);病毒非结构蛋白质类(Viral Nonstructural Proteins);病毒复制(Virus Replication)
DOI
10.1128/AAC.00399-13
PMID
23836176
发布时间
2024-01-09
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