Genome-wide DNA methylation analysis of systemic lupus erythematosus reveals persistent hypomethylation of interferon genes and compositional changes to CD4+ T-cell populations.
第一作者:
Devin M,Absher
第一单位:
HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, USA. dabsher@hudsonalpha.org
作者:
医学主题词
抗原, CD19(Antigens, CD19);B-淋巴细胞(B-Lymphocytes);CD4阳性T淋巴细胞(CD4-Positive T-Lymphocytes);细胞谱系(Cell Lineage);CpG岛(CpG Islands);DNA甲基化(DNA Methylation);表观基因组学(Epigenomics);基因组, 人(Genome, Human);人类(Humans);干扰素类(Interferons);红斑狼疮, 系统性(Lupus Erythematosus, Systemic);启动区, 遗传(Promoter Regions, Genetic);T淋巴细胞, 调节性(T-Lymphocytes, Regulatory)
DOI
10.1371/journal.pgen.1003678
PMID
23950730
发布时间
2022-03-11
- 浏览35
PLoS genetics
e1003678页
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