Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells.
第一作者:
Stefani,Spranger
第一单位:
Department of Pathology, Section of Hematology/Oncology, University of Chicago, IL 60637, USA.
作者:
医学主题词
动物(Animals);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);细胞增殖(Cell Proliferation);炎症趋化因子类(Chemokines);叉头转录因子类(Forkhead Transcription Factors);人类(Humans);干扰素γ(Interferon-gamma);淋巴细胞活化(Lymphocyte Activation);黑色素瘤(Melanoma);黑色素瘤, 实验性(Melanoma, Experimental);小鼠(Mice);肿瘤转移(Neoplasm Metastasis);T淋巴细胞, 调节性(T-Lymphocytes, Regulatory);肿瘤微环境(Tumor Microenvironment);增量调节(Up-Regulation);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1126/scitranslmed.3006504
PMID
23986400
发布时间
2022-04-09
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Science translational medicine
200ra116页
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