Down-regulated peroxisome proliferator-activated receptor γ (PPARγ) in lung epithelial cells promotes a PPARγ agonist-reversible proinflammatory phenotype in chronic obstructive pulmonary disease (COPD).

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第一作者： Sowmya P,Lakshmi

第一单位： Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213; Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania 15240.

作者： Sowmya P,Lakshmi ^[1] ; Aravind T,Reddy ^[1] ; Yingze,Zhang ^[2] ; Frank C,Sciurba ^[2] ; Rama K,Mallampalli ^[1] ; Steven R,Duncan ^[2] ; Raju C,Reddy ^[3]

作者单位： Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213; Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania 15240. ^[1] Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213. ^[2] Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213; Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania 15240. Electronic address: reddyrc@upmc.edu. ^[3]

关键词 Chromatin Histone Modification Cigarette Smoke Glucocorticoid Receptor Histone Deacetylase Human Bronchial Epithelial Cells I-kappa-B Kinase Inflammation NF-kappa B (NF-KB)Oxidative Stress