Methylglyoxal produced by amyloid-β peptide-induced nitrotyrosination of triosephosphate isomerase triggers neuronal death in Alzheimer's disease.-论文-万方医学网

第一作者： Marta,Tajes

第一单位： Laboratory of Molecular Physiology and Channelopathies, Departament de Ciències Experimentals i de la Salut (DCEXS), Universitat Pompeu Fabra (UPF), Barcelona, Spain.

作者： Marta,Tajes ^[1] ; Abel,Eraso-Pichot ^[1] ; Fanny,Rubio-Moscardó ^[1] ; Biuse,Guivernau ^[1] ; Eva,Ramos-Fernández ^[1] ; Mònica,Bosch-Morató ^[1] ; Francesc Xavier,Guix ^[1] ; Jordi,Clarimón ^[2] ; Gian Pietro,Miscione ^[3] ; Mercé,Boada ^[4] ; Gabriel,Gil-Gómez ^[5] ; Toshiharu,Suzuki ^[6] ; Henrik,Molina ^[7] ; Jordi,Villà-Freixa ^[8] ; Rubén,Vicente ^[1] ; Francisco J,Muñoz ^[1]

作者单位： Laboratory of Molecular Physiology and Channelopathies, Departament de Ciències Experimentals i de la Salut (DCEXS), Universitat Pompeu Fabra (UPF), Barcelona, Spain. ^[1] Alzheimer Laboratory, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain. ^[2] Computational Biochemistry and Biophysics Laboratory, Research Program on Biomedical Informatics, DCEXS, IMIM/UPF, Barcelona, Spain Dipartimento di Chimica "G. Ciamician", Universitá degli Studi di Bologna, Italy. ^[3] Memory Clinic, Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain Neurology Department, Hospital Universitari Vall d'Hebron-Institut de Recerca, Universitat Autònoma de Barcelona (VHIR-UAB), Barcelona, Spain. ^[4] IMIM (Institut Hospital del Mar d'Investigacions Mèdiques), Barcelona, Spain. ^[5] Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan. ^[6] Proteomics Unit, DCEXS, UPF and Centre de Regulació Genómica (CRG), Barcelona, Spain. ^[7] Computational Biochemistry and Biophysics Laboratory, Research Program on Biomedical Informatics, DCEXS, IMIM/UPF, Barcelona, Spain Escola Politécnica Superior, Universitat de Vic, Spain. ^[8]

主题词老年人(Aged);阿尔茨海默病(Alzheimer Disease);淀粉样β肽类(Amyloid beta-Peptides);淀粉样β蛋白前体(Amyloid beta-Protein Precursor);动物(Animals);细胞凋亡(Apoptosis);脑(Brain);细胞系, 肿瘤(Cell Line, Tumor);细胞存活(Cell Survival);计算机模拟(Computer Simulation);女(雌)性(Female);人类(Humans);男(雄)性(Male);小鼠, 转基因(Mice, Transgenic);中年人(Middle Aged);模型, 分子(Models, Molecular);神经元(Neurons);肽碎片(Peptide Fragments);早老素1(Presenilin-1);丙酮醛(Pyruvaldehyde);丙糖磷酸异构酶(Triose-Phosphate Isomerase)

DOI 10.3233/JAD-131685

PMID 24614897

发布时间 2022-04-10

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Methylglyoxal produced by amyloid-β peptide-induced nitrotyrosination of triosephosphate isomerase triggers neuronal death in Alzheimer's disease.

Journal of Alzheimer's disease

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Journal of Alzheimer's disease

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Methylglyoxal produced by amyloid-β peptide-induced nitrotyrosination of triosephosphate isomerase triggers neuronal death in Alzheimer's disease.

Journal of Alzheimer's disease

相似文献

Journal of Alzheimer's disease

相关期刊

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