换一批Lead optimization of a novel series of imidazo[1,2-a]pyridine amides leading to a clinical candidate (Q203) as a multi- and extensively-drug-resistant anti-tuberculosis agent.
第一作者：
Sunhee,Kang
第一单位：
Medicinal and Bioorganic Chemistry Group, ‡Antibacterial Drug Discovery Group, and §Drug Metabolism and Pharmacokinetics Group, Institut Pasteur Korea , 16 Daewnagpangyo-ro, 712 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea.
作者：
医学主题词
动物(Animals);抗结核药(Antitubercular Agents);抗药性, 多种, 细菌(Drug Resistance, Multiple, Bacterial);人类(Humans);咪唑类(Imidazoles);巨噬细胞(Macrophages);小鼠(Mice);微粒体, 肝(Microsomes, Liver);结核分枝杆菌(Mycobacterium tuberculosis);吡啶类(Pyridines);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);构效关系(Structure-Activity Relationship);结核, 抗多种药物性(Tuberculosis, Multidrug-Resistant)
DOI
10.1021/jm5003606
PMID
24870926
发布时间
2014-06-26
- 浏览69
Journal of medicinal chemistry
5293-305页
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