首页> Journal of immunology (Baltimore, Md. : 1950)> Neutrophil IL-1β processing induced by pneumolysin is mediated by the NLRP3/ASC inflammasome and caspase-1 activation and is dependent on K+ efflux.

Neutrophil IL-1β processing induced by pneumolysin is mediated by the NLRP3/ASC inflammasome and caspase-1 activation and is dependent on K+ efflux.

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第一作者： Mausita,Karmakar

第一单位： Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH 44106;

作者： Mausita,Karmakar ^[1] ; Michael,Katsnelson ^[2] ; Hesham A,Malak ^[3] ; Neil G,Greene ^[4] ; Scott J,Howell ^[1] ; Amy G,Hise ^[5] ; Andrew,Camilli ^[4] ; Aras,Kadioglu ^[3] ; George R,Dubyak ^[2] ; Eric,Pearlman ^[6]

作者单位： Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH 44106; ^[1] Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106; ^[2] Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool L69 7BE, United Kingdom; ^[3] Graduate Program in Molecular Microbiology, Department of Molecular Biology and Microbiology and Howard Hughes Medical Institute, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111; and. ^[4] Department of Medicine, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106. ^[5] Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH 44106; eric.pearlman@case.edu. ^[6]

医学主题词动物(Animals);凋亡调节蛋白质类(Apoptosis Regulatory Proteins);细菌蛋白质类(Bacterial Proteins);印迹法, 蛋白质(Blotting, Western);CARD信号接头蛋白质类(CARD Signaling Adaptor Proteins);载体蛋白质类(Carrier Proteins);半胱氨酸天冬氨酸蛋白酶1(Caspase 1);疾病模型, 动物(Disease Models, Animal);酶激活(Enzyme Activation);酶联免疫吸附测定(Enzyme-Linked Immunosorbent Assay);眼感染, 细菌性(Eye Infections, Bacterial);流式细胞术(Flow Cytometry);荧光抗体技术(Fluorescent Antibody Technique);人类(Humans);炎性体(Inflammasomes);白细胞介素1β(Interleukin-1beta);角膜炎(Keratitis);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);中性白细胞(Neutrophils);肺炎球菌感染(Pneumococcal Infections);钾(Potassium);信号传导(Signal Transduction);分光光度法, 原子(Spectrophotometry, Atomic);链球菌溶血素类(Streptolysins)

DOI 10.4049/jimmunol.1401624

PMID 25609842

发布时间 2018-11-13

基金项目

P30 EY011373/EY/NEI NIH HHS/United States R01 GM036387/GM/NIGMS NIH HHS/United States R01 EY014362/EY/NEI NIH HHS/United States P30 CA043703/CA/NCI NIH HHS/United States R01 EY14362/EY/NEI NIH HHS/United States UL1 TR000439/TR/NCATS NIH HHS/United States R01 GM36387/GM/NIGMS NIH HHS/United States Howard Hughes Medical Institute/United States I01 BX002607/BX/BLRD VA/United States P30 CA43703/CA/NCI NIH HHS/United States P30 EY11373/EY/NEI NIH HHS/United States T32 GM007250/GM/NIGMS NIH HHS/United States

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