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Identification of the DEAD box RNA helicase DDX3 as a therapeutic target in colorectal cancer.

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第一作者： Marise R,Heerma van Voss

第一单位： Department of Radiology and Radiological Science, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.;Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.

作者： Marise R,Heerma van Voss ^[1] ; Farhad,Vesuna ^[2] ; Kari,Trumpi ^[3] ; Justin,Brilliant ^[2] ; Cynthia,Berlinicke ^[4] ; Wendy,de Leng ^[5] ; Onno,Kranenburg ^[3] ; G Johan,Offerhaus ^[5] ; Horst,Bürger ^[6] ; Elsken,van der Wall ^[7] ; Paul J,van Diest ^[5] ; Venu,Raman ^[8]

作者单位： Department of Radiology and Radiological Science, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.;Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands. ^[1] Department of Radiology and Radiological Science, Johns Hopkins University, School of Medicine, Baltimore, MD, USA. ^[2] Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands. ^[3] Wilmer Eye Institute, Johns Hopkins University, School of Medicine, Baltimore, MD, USA. ^[4] Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands. ^[5] Institute of Pathology, Paderborn, Germany. ^[6] Department of Internal Medicine, University Medical Center Utrecht, Utrecht, The Netherlands. ^[7] Department of Radiology and Radiological Science, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.;Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.;Department of Oncology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA. ^[8]

关键词 DEAD-box RNA helicases Wnt signaling colorectal cancer small molecule inhibitors β-catenin