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Development and potential applications of CRISPR-Cas9 genome editing technology in sarcoma.

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第一作者： Tang,Liu

第一单位： Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Jackson 1115, Boston, MA 02114, United States; Department of Orthopaedic, the 2nd Xiangya Hospital of Central South University, 139 Renmin Road, Changsha, Hunan 410011, China.

作者： Tang,Liu ^[1] ; Jacson K,Shen ^[2] ; Zhihong,Li ^[3] ; Edwin,Choy ^[2] ; Francis J,Hornicek ^[2] ; Zhenfeng,Duan ^[4]

作者单位： Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Jackson 1115, Boston, MA 02114, United States; Department of Orthopaedic, the 2nd Xiangya Hospital of Central South University, 139 Renmin Road, Changsha, Hunan 410011, China. ^[1] Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Jackson 1115, Boston, MA 02114, United States. ^[2] Department of Orthopaedic, the 2nd Xiangya Hospital of Central South University, 139 Renmin Road, Changsha, Hunan 410011, China. ^[3] Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Jackson 1115, Boston, MA 02114, United States. Electronic address: zduan@mgh.harvard.edu. ^[4]

关键词 CRISPR-Cas9 Cancer modeling Gene therapy Sarcoma

医学主题词动物(Animals);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);基因打靶(Gene Targeting);遗传关联研究(Genetic Association Studies);人类(Humans);突变(Mutation);肉瘤(Sarcoma)

DOI 10.1016/j.canlet.2016.01.030

PMID 26806808

发布时间 2018-11-13

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