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Mutations in genes encoding condensin complex proteins cause microcephaly through decatenation failure at mitosis.

作者单位: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, United Kingdom. [1] South East Scotland Cytogenetics Service, Western General Hospital, Edinburgh EH4 2XU, United Kingdom. [2] Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin 9054, New Zealand. [3] West of Scotland Genetic Service, Southern General Hospital, Glasgow G51 4TF, United Kingdom. [4] Centro de Genética Médica Doutor Jacinto Magalhães, Centro Hospitalar do Porto, 4099-028 Porto, Portugal. [5] Instituto de Biologia Molecular e Celular (IBMC), 4150 Porto, Portugal. [6] Instituto de Investigação e Inovação em Saúde (I3S), Universidade do Porto, 4200-135 Porto, Portugal. [7] Division of Genetics, Department of Pediatrics, A.I. duPont Hospital for Children, Wilmington, Delaware 19803, USA. [8] Sarah M. and Charles E. Seay Center for Musculoskeletal Research, Texas Scottish Rite Hospital for Children, Dallas, Texas 75219, USA. [9] Department of Orthopedic Surgery, Texas Scottish Rite Hospital for Children, Dallas, Texas 75219, USA. [10] Department of Pediatrics, Texas Scottish Rite Hospital for Children, Dallas, Texas 75219, USA. [11] McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas 75350, USA. [12] Department of Radiology, Royal Hospital for Sick Children, Edinburgh EH9 1LF, United Kingdom. [13] Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh 226014, India. [14] Biosciences, Research Institute for Health and Environment, Brunel University, London UB8 3PH, United Kingdom. [15]
DOI: 10.1101/gad.286351.116
PMID: 27737959
发布时间: 2022-01-29
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