换一批Identification of a deoxyribonuclease activity in the nuclei of the cervical carcinoma HeLa.
摘要：
A deoxyribonuclease activity has been identified in the nuclei of the human cervical carcinoma HeLa. This activity has the novel property of existing as a single strand specific endo- and exodeoxyribonuclease activity. These activities are ionic strength sensitive, with retardation of activity occurring at 50 mM NaCl and above, with the Mn++ ion preferred over the Mg++ ion as activating cation. This activity extensively damages DNA via its single strand nicking and gaping activity. The method used to solubilize this activity as well as the enzyme's characteristics are discussed.
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作者：
S A,Quarless
期刊：
主题词：
癌(Carcinoma);细胞核(Cell Nucleus);脱氧核糖核酸酶类(Deoxyribonucleases);外切核酸酶类(Exonucleases);女(雌)性(Female);人类(Humans);动力学(Kinetics);分子量(Molecular Weight);容积渗克分子浓度(Osmolar Concentration);宫颈肿瘤(Uterine Cervical Neoplasms)
PMID：
3017542
发布时间：
2006-11-15
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