换一批Lipid peroxidation induced by cyclophosphamide.
摘要：
Intraperitoneal administration of a single dose of cyclophosphamide (CP) to rats was found to produce hepatic glutathione depletion and to enhance NADPH-mediated lipid peroxidation in the 15,000 x g supernatant fraction of the liver. These effects were associated with CP in a dose- and a time-dependent manner. The data suggest that the glutathione depletion is, at least in part, responsible for the enhancement in lipid peroxidation induced by CP.
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作者：
M J,Berrigan [1]
;
R F,Struck [2]
;
H L,Gurtoo [3]
作者单位：
Department of Experimental Therapeutics
[1]
Roswell Park Memorial Institute
[2]
New York State Department of Health
[3]
Buffalo 14263.
[4]
期刊：
主题词：
动物(Animals);环磷酰胺(Cyclophosphamide);剂量效应关系, 药物(Dose-Response Relationship, Drug);谷胱甘肽(Glutathione);过氧化脂质类(Lipid Peroxides);肝(Liver);男(雄)性(Male);丙二醛(Malondialdehyde);NADP(NADP);大鼠(Rats);大鼠, 近交系(Rats, Inbred Strains)
PMID：
3435898
发布时间：
2013-11-21
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