换一批Grossularine-1 and grossularine-2, alpha carbolines from Dendrodoa grossularia, as possible intercalative agents.
摘要：
Dendrodoine A, grossularines-1 and -2, metabolites isolated from the tunicate Dendrodoa grossularia, have exhibited a cytotoxic activity on L1210 leukemia cells in culture. The inhibition of DNA synthesis induced by grossularines and the plane structure of the alpha-carboline common moiety were in favor of an intercalative process for their mechanism of action. In fact, the results of viscometry, fluorescence quenching and DNA melting experiments clearly indicated the intercalative properties of grossularine-2 explained by its quasi-planar structure and the non-intercalative DNA binding of grossularine-1 explained by the presence of a bulky indole chain at the 2-position of the alpha-carboline ring.
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作者：
N,Helbecque [1]
;
C,Moquin [2]
;
J L,Bernier [3]
;
E,Morel ;
M,Guyot ;
J P,Henichart
作者单位：
Département de Biochimie
[1]
Université de Lille II
[2]
France.
[3]
期刊：
主题词：
动物(Animals);咔啉类(Carbolines);牛(Cattle);DNA(DNA);吲哚类(Indoles);嵌入剂(Intercalating Agents);核酸变性作用(Nucleic Acid Denaturation);光谱法, 荧光(Spectrometry, Fluorescence);分光光度法(Spectrophotometry);热力学(Thermodynamics);噻二唑类(Thiadiazoles);肿瘤细胞, 培养的(Tumor Cells, Cultured)
PMID：
3435899
发布时间：
2003-11-14
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