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dRTEL1 is essential for the maintenance of Drosophila male germline stem cells.

摘要:

Stem cells have the potential to maintain undifferentiated state and differentiate into specialized cell types. Despite numerous progress has been achieved in understanding stem cell self-renewal and differentiation, many fundamental questions remain unanswered. In this study, we identify dRTEL1, the Drosophila homolog of Regulator of Telomere Elongation Helicase 1, as a novel regulator of male germline stem cells (GSCs). Our genome-wide transcriptome analysis and ChIP-Seq results suggest that dRTEL1 affects a set of candidate genes required for GSC maintenance, likely independent of its role in DNA repair. Furthermore, dRTEL1 prevents DNA damage-induced checkpoint activation in GSCs. Finally, dRTEL1 functions to sustain Stat92E protein levels, the key player in GSC maintenance. Together, our findings reveal an intrinsic role of the DNA helicase dRTEL1 in maintaining male GSC and provide insight into the function of dRTEL1.

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作者: Ying,Yang [1] ; Ruiyan,Kong [2] ; Feng Guang,Goh [3] ; W Gregory,Somers [4,5] ; Gary R,Hime [2] ; Zhouhua,Li [3] ; Yu,Cai [4,6]
作者单位: Temasek Life Sciences Laboratory [1] National University of Singapore [2] Singapore [3] Singapore. [4] Department of Biological Sciences [5] Department of Pathology [6] Peking University Health Science Center [7] Beijing [8] China. [9] College of Life Sciences [10] Capital Normal University [11] Department of Anatomy and Physiology [12] The University of Melbourne [13] Melbourne [14] Australia. [15]
期刊:
DOI: 10.1371/journal.pgen.1009834
PMID: 34644293
发布时间: 2021-11-30
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