换一批Nature of the binding of activated cyclophosphamide to calf thymus DNA and pBR-322 plasmid DNA.
摘要：
Differentially radiolabeled cyclophosphamide (CP) was metabolized with a reconstituted cytochrome P-450 system in the presence of calf thymus DNA or plasmid pBR-322 DNA. The isolated DNA was subjected to agarose gel electrophoresis and the associated radioactivity was determined. The majority (greater than 90%) of the initial DNA-bound radioactive metabolites dissociated from the DNA upon gel electrophoresis. The results are discussed in context to the binding of activated CP to DNA and the nature of the binding.
更多
作者：
S K,Bansal ;
J H,Love ;
M B,Faletto ;
H L,Gurtoo ;
R F,Struck
期刊：
主题词：
动物(Animals);生物转化(Biotransformation);环磷酰胺(Cyclophosphamide);细胞色素P450酶系统(Cytochrome P-450 Enzyme System);DNA(DNA);DNA, 细菌(DNA, Bacterial);微粒体, 肝(Microsomes, Liver);胸腺(Thymus Gland)
PMID：
3742481
发布时间：
2014-11-20
- 翻译满意度评价：
- 提交
- 浏览：6
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文
