换一批The reversal of effects of methotrexate on toxicity and glucose transport reduction by thymidine in Ehrlich ascites tumor bearing mice.
摘要：
Methotrexate (MTX) suppressed the growth of Ehrlich ascites tumor cells in vivo and reduced the cellular uptake of glucose and the density of glucose transporters on the tumor cell surface. MTX inhibition of tumor growth was partially prevented by concurrent administration of thymidine. At the same time, the rate of cellular glucose uptake, the density of glucose transporters on the cell as well as the extent of thymidine, uridine and leucine incorporation were significantly increased.
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主题词：
动物(Animals);结合部位(Binding Sites);生物转运, 主动(Biological Transport, Active);癌, Ehrlich瘤(Carcinoma, Ehrlich Tumor);细胞分裂(Cell Division);细胞膜(Cell Membrane);细胞松弛素B(Cytochalasin B);脱氧糖类(Deoxy Sugars);脱氧葡萄糖(Deoxyglucose);葡萄糖(Glucose);甲氨蝶呤(Methotrexate);小鼠(Mice);小鼠, 近交ICR(Mice, Inbred ICR);胸苷(Thymidine)
PMID：
3802046
发布时间：
2013-11-21
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