换一批Enhancement of stability of 7 beta,8 alpha-dihyroxy-9 alpha epoxybenzo(a)pyrene by complex formation with serum albumin.
摘要：
The biologically active and chemically unstable metabolite of benzo(a)pyrene, 7 beta,8 alpha-dihydroxy-9 alpha, 10 alpha-epoxybenzo(a)pyrene (BPDE), binds to human serum albumin in aqueous solutions with an association constant of 2.6 X 10(5)M-1. At pH 7.2, 24 degrees C and in 5mM sodium cacodylate buffer solution, this binding increases the lifetime of the diol epoxide by a factor of nearly 3. It is suggested that the formation of such physical complexes with proteins having hydrophobic interiors or with lipids may provide a mechanism by which highly reactive metabolites are transported from the site of metabolic synthesis to biological target molecules (e.g., DNA), in a reactive aqueous environment.
更多
作者：
C J,Roche ;
D,Zinger ;
N E,Geacintov ;
R G,Harvey
期刊：
主题词：
7,8-二氢-7,8-二羟苯(a)并芘9,10-氧化物(7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide);苯并芘类(Benzopyrenes);药物稳定性(Drug Stability);人类(Humans);动力学(Kinetics);蛋白质结合(Protein Binding);血清白蛋白(Serum Albumin);分光光度法, 紫外线(Spectrophotometry, Ultraviolet)
PMID：
3928138
发布时间：
2007-11-14
- 翻译满意度评价：
- 提交
- 浏览：12
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文
