换一批Abnormal protein synthesis in malignant melanoma cells.
摘要：
Abnormal proteins in neoplastic cells are present in a variety of animal tumor systems. Our laboratory has isolated several of these abnormal proteins from murine malignant melanoma by preparative gel electrophoresis; these proteins are similar in many respects to analogous proteins found in normal tissues. Examination of these proteins by polyacrylamide gel electrophoresis, amino acid analysis, carboxy and amino terminal analysis and peptide mapping after cyanogen bromide cleavage, supports the theory that these abnormal proteins are the result of deleted sequences in the peptide chain during the attempted synthesis of normal proteins in neoplastic tissue.
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作者：
V J,Hearing ;
J M,Nicholson
期刊：
主题词：
氨基酸类(Amino Acids);动物(Animals);溴化氰(Cyanogen Bromide);电泳, 聚丙烯酰氨凝胶(Electrophoresis, Polyacrylamide Gel);黑色素瘤(Melanoma);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);分子量(Molecular Weight);肿瘤蛋白质类(Neoplasm Proteins);肿瘤, 实验性(Neoplasms, Experimental);肽碎片(Peptide Fragments)
PMID：
552907
发布时间：
2013-11-21
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