换一批DNA-dependent RNA polymerase from T8 Guerin tumor.
摘要：
DNA-dependent RNA polymerases from nuclei of T8 Guerin tumor were studied. Two enzymes were purified several hundred times by the use of ammonium sulfate precipitation, DEAE-cellulose and phosphocellulose chromatography. One of them belongs to A(I) RNA polymerases and the second to B(II) as was established from their metal and ionic strength requirements. activity in the presence of native and denatured DNA and the resistance to a-amanitin inhibition. The quantity of class A enzyme was increased compared to B, a fact observed with most neoplastic tissues so far studied. This increase of the polymerase responsible for ribosomal RNA synthesis could probably be related to malignant transformation in animals.
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作者：
O,Antonoglou ;
L,Boutis ;
E,Pavlidou ;
E,Kavoukopoulos ;
A,Trakatellis
期刊：
主题词：
腺癌(Adenocarcinoma);动物(Animals);细胞核(Cell Nucleus);指导DNA的RNA聚合酶类(DNA-Directed RNA Polymerases);女(雌)性(Female);男(雄)性(Male);肿瘤, 实验性(Neoplasms, Experimental);RNA聚合酶Ⅰ(RNA Polymerase I);RNA聚合酶Ⅱ(RNA Polymerase II);大鼠(Rats);肉瘤, 实验性(Sarcoma, Experimental);子宫肿瘤(Uterine Neoplasms)
PMID：
567523
发布时间：
2016-11-23
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