换一批C-alkylation of N-acetoxy-N-2-acetylaminofluorene: effects on its reaction with DNA in vitro.
摘要：
In vitro reactions of DNA with N-acetoxy-N-2-acetylaminofluorene (N-AcO-AAF), N-acetoxy-7-ethyl-N-2-acetylaminofluorene (N-AcO-EtAAF), N-acetoxy-7-n-butyl-N-2-acetylaminofluorene (N-AcO-But-AAF) are compared. C-alkylation of N-AcO-AAF affects the reactivity of the metabolite towards DNA. The electronic effect and the size of alkyl group seem to determine the reactivity of the metabolite. Although the adducts are about the same for the three metabolites, the proportion of guanine-C-8 adducts diminishes with an increase in the size of the alkyl group.
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主题词：
2-乙酰氨基芴(2-Acetylaminofluorene);乙酰氧乙酰氨基芴(Acetoxyacetylaminofluorene);烷化作用(Alkylation);DNA(DNA);构效关系(Structure-Activity Relationship)
PMID：
6088032
发布时间：
2013-11-21
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