换一批DNA polymerases during tumor growth.
摘要：
DNA polymerase activity was studied as a function of stage of tumor growth and correlated with DNA synthesis measured by 3H-TdR uptake. Considerable variations in DNA synthesis activity occur at different growth stages and following host death. DNA alpha-polymerase activity did vary with growth stage in the ascites tumor. However, it did not have a clear correlation with DNA synthesis or with tumor growth. No striking fall in DNA polymerase enzyme levels occurred as the ascites tumor reached stationary phase in contrast to reports in some cell culture systems. A decrease occurred with advanced tumor stage and after host death. DNA beta-polymerase activity did not change with tumor growth stage.
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作者：
Y,Maruyama ;
M,Deland
期刊：
主题词：
动物(Animals);细胞计数(Cell Count);细胞分裂(Cell Division);细胞核(Cell Nucleus);细胞质(Cytoplasm);DNA聚合酶Ⅰ(DNA Polymerase I);DNA聚合酶Ⅱ(DNA Polymerase II);DNA, 肿瘤(DNA, Neoplasm);指导DNA的DNA聚合酶(DNA-Directed DNA Polymerase);女(雌)性(Female);淋巴瘤(Lymphoma);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);肿瘤, 实验性(Neoplasms, Experimental)
PMID：
616318
发布时间：
2020-12-09
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