换一批In vivo effects of cannabinoids on macromolecular biosynthesis in Lewis lung carcinomas.
摘要：
Cannabinoids represent a novel class of drugs active in increasing the life span mice carrying Lewis lung tumors and decreasing primary tumor size. In the present studies, the effects of delta9-THC, delta8-THC, and cannabidiol on tumor macromolecular biosynthesis were studied. These drugs inhibit thymidine-3H incorporation into DNA acutely, but did not inhibit leucine uptake into tumor protein. At 24 h after treatment, cannabinoids did not inhibit thymidine-3H incorporation into DNA, leucine-3H uptake into protein or cytidine-3H into RNA.
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作者：
M A,Friedman
主题词：
动物(Animals);大麻二酚(Cannabidiol);大麻酚类(Cannabinoids);DNA, 肿瘤(DNA, Neoplasm);肺肿瘤(Lung Neoplasms);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 近交DBA(Mice, Inbred DBA);肿瘤蛋白质类(Neoplasm Proteins);肿瘤, 实验性(Neoplasms, Experimental);RNA, 肿瘤(RNA, Neoplasm);组织分布(Tissue Distribution)
PMID：
616322
发布时间：
2013-11-21
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