换一批Membrane associated proteins and malignancy: an experimental hypothesis.
摘要：
Normal human lymphocytes and human tumor cell lines were labeled with an apolar fluorescent probe (1, 6-diphenyl-1, 3, 5-hexatriene), and fluoresence polarization (P) values were determined. The arguments presented in this study suggest that although P values represent an intricate average of all labeled hydrophobic regions of the cell (phospholipid bilayers, membrane proteins and enzymes, etc.), to a large extent, interactions of the probe with membrane proteins are of primary importance. The lower P values obtained with the tumor cell lines, compared with the normal lymphocytes, were interpreted as indicating alterations in either the structure or concentration of a membrane associated protein(s).
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作者：
B,Mély-Goubert ;
M H,Freedman
期刊：
主题词：
动物(Animals);卡西霉素(Calcimycin);细胞膜(Cell Membrane);二苯己三烯(Diphenylhexatriene);人类(Humans);白血病(Leukemia);淋巴细胞(Lymphocytes);膜蛋白质类(Membrane Proteins);小鼠(Mice);小鼠, 近交CBA(Mice, Inbred CBA);肿瘤蛋白质类(Neoplasm Proteins);肿瘤(Neoplasms);光谱法, 荧光(Spectrometry, Fluorescence)
PMID：
6777032
发布时间：
2013-11-21
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